Cytolytic responses to anti-KIR mAbs in polyclonal NK cell lines from LDGL patients. Seven NKLGL cell lines derived from the indicated patients and 2 controls were analyzed for cytolytic responses in a redirected killing assay either in the absence or in the presence of different mAbs: EB6 (a), GL183 (b), FES172 (c), Z27 (d), or anti-CD16 (e). The latter has been indicated with black bars and constitutes a positive control for each experiment. The spontaneous lysis of P815 target cells is represented by the horizontal line in each graph. The bars over the line indicate increase of cytotoxicity, whereas those under the line indicate inhibition. The E/T ratio was 5:1.