Figure 2.
Figure 2. Inhibition of thrombasthenic platelet adhesion to collagen and GFOGER-GPP. Thrombasthenic platelets were incubated with GR144053F (2 μM), bacitracin A (3 mM), DTNB (2.5 mM), or anti-PDI Fab fragments (400 μg/mL) as indicated, then allowed to adhere to the indicated substrates for 1 hour using adhesion method B. A single experiment performed in triplicate (mean ± SD) was performed with platelets from each of 2 donors, A and B. Residual adhesion is expressed relative to untreated controls. ▨ indicates collagen; ▪, GFOGER; and □, CRP.

Inhibition of thrombasthenic platelet adhesion to collagen and GFOGER-GPP. Thrombasthenic platelets were incubated with GR144053F (2 μM), bacitracin A (3 mM), DTNB (2.5 mM), or anti-PDI Fab fragments (400 μg/mL) as indicated, then allowed to adhere to the indicated substrates for 1 hour using adhesion method B. A single experiment performed in triplicate (mean ± SD) was performed with platelets from each of 2 donors, A and B. Residual adhesion is expressed relative to untreated controls. ▨ indicates collagen; ▪, GFOGER; and □, CRP.

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