Figure 1.
Figure 1. αCD154 + DST delays skin graft rejection by alloreactive Tg CD4+ T cells. On day –1, C57BL/6 RAG KO mice were injected with TEa Tg T cells with or without CB6F1 spleen cells followed by a CB6F1 skin graft on day 0. Mice were treated with αCD154 or control H-Ig and scored for graft rejection 3 times per week. Grafts were considered rejected when completely necrotic, or when less than 20% of the graft remained. Data were pooled from 3 separate experiments. (▾ represents H-Ig [n = 13]; ▪, DST [n = 16]; ♦, αCD154 [n = 18]; and •, DST +αCD154 [n = 17].)

αCD154 + DST delays skin graft rejection by alloreactive Tg CD4+ T cells. On day –1, C57BL/6 RAG KO mice were injected with TEa Tg T cells with or without CB6F1 spleen cells followed by a CB6F1 skin graft on day 0. Mice were treated with αCD154 or control H-Ig and scored for graft rejection 3 times per week. Grafts were considered rejected when completely necrotic, or when less than 20% of the graft remained. Data were pooled from 3 separate experiments. (▾ represents H-Ig [n = 13]; ▪, DST [n = 16]; ♦, αCD154 [n = 18]; and •, DST +αCD154 [n = 17].)

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