Sequence of the proximal 5′-flanking region of the vitamin K–dependent carboxylase gene. Transcription factor consensus binding sites are boxed and labeled as indicated. UPE indicates upstream promoter element; a solid dot (•), G hypomethylation as indicated in Figure 7; and a plus sign (+), G hypermethylation as indicated in Figure 7. Numbering is relative to the transcription start site at + 1, indicated with an arrow.