HA induces FGF-2 mRNA expression by HCs. Panel A shows RT-PCR analysis of FGF-2 and L27 (a housekeeping gene) mRNA from the malignant cells of 5 patients with HCL. The cells were cultured for 3 hours on HA-coated (HA) or uncoated plastic (PL). Panel B is a graphic representation of the data shown in panel A, where the intensities of the FGF-2 bands (mean ± 1 SD) were measured by densitometry and normalized against the loading control (L27).