Proposed model for BCR signaling to Ras based on convergent diacylyglycerol signaling through PKC and RasGRP3. BCR ligation activates protein tyrosine kinases such as Btk, Lyn, and Syk (PTK), leading to the phosphorylation of adaptor proteins such as BLNK (A). Phospholipase C-γ2 (PLC) is also tyrosine phosphorylated and is recruited to the membrane by association with adaptors, where it can stimulate hydrolysis of PIP₂ (not shown) releasing DAG. DAG messenger recruits and activates RasGRP3 and some forms of PKC; this is followed by regulatory phosphorylation of the former by the latter.