Figure 2.
Figure 2. T-cell counts in surviving patients. (A) CD3 counts, (B) CD4 counts, and (C) CD8 counts. The Y-axis maximum in each graft does not show the peak from early oligoclonal proliferations. The early oligoclonal peaks for patients DIG001, DIG009, and DIG010 are indicated on the grafts. Only 4 years of data are depicted because only one patient, DIG001, is more than 4 years from transplantation. The most recent CD3, CD4, and CD8 counts for patient DIG001 are 337/mm3, 178/mm3, and 112/mm3 from 8 years after transplantation, respectively. The normal CD3 T-cell count for age 2 days to 11 months is 1700 to 3600/mm3, for age 1 to 6 years is 1800 to 3000/mm3, for age 7 to 17 years is 1400 to 2000/mm3.35 The normal CD4 T-cell count for age 2 days to 11 months is 1700 to 2800/mm3, for age 1 to 6 years is 1000 to 1800/mm3, for age 7 to 17 years is 700 to 1100/mm3.35 The normal CD8 T-cell count for age 2 days to 11 months is 800 to 1200/mm3, for age 1 to 6 years is 800 to 1500/mm3, for age 7 to 17 years is 600 to 900/mm3.35 These ranges all reflect the 25th to 75th percentiles.35

T-cell counts in surviving patients. (A) CD3 counts, (B) CD4 counts, and (C) CD8 counts. The Y-axis maximum in each graft does not show the peak from early oligoclonal proliferations. The early oligoclonal peaks for patients DIG001, DIG009, and DIG010 are indicated on the grafts. Only 4 years of data are depicted because only one patient, DIG001, is more than 4 years from transplantation. The most recent CD3, CD4, and CD8 counts for patient DIG001 are 337/mm3, 178/mm3, and 112/mm3 from 8 years after transplantation, respectively. The normal CD3 T-cell count for age 2 days to 11 months is 1700 to 3600/mm3, for age 1 to 6 years is 1800 to 3000/mm3, for age 7 to 17 years is 1400 to 2000/mm3.35  The normal CD4 T-cell count for age 2 days to 11 months is 1700 to 2800/mm3, for age 1 to 6 years is 1000 to 1800/mm3, for age 7 to 17 years is 700 to 1100/mm3.35  The normal CD8 T-cell count for age 2 days to 11 months is 800 to 1200/mm3, for age 1 to 6 years is 800 to 1500/mm3, for age 7 to 17 years is 600 to 900/mm3.35  These ranges all reflect the 25th to 75th percentiles.35 

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