Bacterial outgrowth and mortality. (A-B) S pneumoniae CFUs in the lungs of Wt (□) and PAI-1^-/- (▪) mice at 24 (A) and 48 (B) hours after inoculation. Data are mean ± SE; n = 8 per group per time point. (C) Survival after S pneumoniae inoculation in Wt (▪) and PAI-1^-/- (○) mice. Mortality was assessed twice daily for 10 days; n = 10 per group. ns indicates nonsignificant.