Linear regression analysis of the correlation between the hepatic Hepc/Actin ratio and the serum transferrin saturation in control individuals and untreated HH patients. (A) In control patients, no significant correlation between the hepatic Hepc/Actin ratio and the serum transferrin saturation was found. (B) HH patients with a transferrin saturation above 80% showed a strong inverse correlation between the Hepc/Actin ratio and the serum transferrin saturation. * indicates statistically significant using multiple regression analysis (serum ferritin levels and serum transferrin saturation).