Linear regression analysis of the correlation between the hepatic Hepc/Actin ratio and serum ferritin levels in control individuals and untreated HH patients. (A) In control individuals, the hepatic Hepc/Actin ratio correlated significantly with serum ferritin levels. (B) In iron overloaded HH patients, an inverse correlation between the hepatic Hepc/Actin ratio and serum ferritin levels was observed. * indicates statistically significant using multiple regression analysis (serum ferritin levels and serum transferrin saturation).