Hyperplastic and inflamed cutaneous blood vessels in K14-VEGF transgenic mice. Immunostaining was performed on cryosections of ear skin from wild-type littermate controls (A, D-E) and transgenic mice (B-C, F-G). PECAM staining showed increased vascular density mostly in the papillary dermis in wound-induced psoriasis in the 3-month-old transgenic mice (B). Enlarged vessels in 6-month-old transgenic mice showed vessels enclosed by anastomosing epidermal rete ridges (C). Immunostaining of E-selectin (G) and ICAM-1 (F) showed positive signals on dermal microvessels in transgenic mice (arrowheads). Original magnifications: × 20 (A-C); and × 10 (D-G).