Histologic examination of ear skin from K14-VEGF transgenic mice, using H&E-stained tissue sections. (A) Control, wild-type littermate. Left inset shows epidermis at higher magnification; while right inset shows epidermis is negative for VEGF immunostaining. (B)Transgenic mouse (3 months of age) with edema, mild rete ridge formation on the ventral ear surface (arrows), epidermal acanthosis (left inset), and VEGF immunostaining in epidermis and in dermal microvessels (right inset). (C) Wound-induced rete ridge formation in a 3-month-old VEGF transgenic mouse. (D) Six-month-old VEGF transgenic mice showed spontaneous extensive rete ridge formation and anastomosis. (E) Early-stage human psoriasis shown for comparison. (F) Fully developed human psoriasis shown for comparison. Panels E-F reproduced with permission from Elder et al⁴⁶  and Nickoloff and Wrone-Smith,²³  respectively. Original magnifications: × 10 (A-D); and × 40 (insets).