Figure 4.
Curative potential of Id-specific CD4+ T cells. Groups of SCID mice (n = 6-7) were injected with 1.25 × 105 F9 cells at day 0 in all graphs. At the indicated time points subsequent to tumor cell injection, mice received 106 CD4+ T cells purified from TCR-transgenic mice. Percent tumor avoidance (short dashes; tumor ≥ 3 mm was defined as tumor take), % survival (long dashes), and tumor size in diameter (solid lines; mm) were recorded (split y-axis). * indicates late emergence of tumors (survival ≥ 60 days). P value in each graph represents comparison with nonreconstituted mice for survival.
