Sensitivity toward tyrosine kinase inhibitors varies between different FLT3 receptor mutants. Ba/F3 FLT3 ITD, Asp835Tyr, Ile836del, and Ile836Met+Arg cells were incubated with increasing concentrations of (A) AG1296, (B) PKC412, and (C) SU5614. Cell viability was determined after 24 hours. Data are presented as percentage of control (DMSO treated) cells. Data represent values ± SD of triplicates. One representative of at least 3 independent experiments is shown.