Figure 1.
Figure 1. Scheme of synthesis and activation of ProVP16-I and -II. The synthesis of ProVP16-I involves the reaction of solketal chloroformate and VP16. ProVP16-II is synthesized from ProVP16-I by acid hydrolysis with the elimination of 2,2 dihydroxypropane. The activation of ProVP16-II to VP16 occurs with the elimination of glycerol and carbon dioxide.

Scheme of synthesis and activation of ProVP16-I and -II. The synthesis of ProVP16-I involves the reaction of solketal chloroformate and VP16. ProVP16-II is synthesized from ProVP16-I by acid hydrolysis with the elimination of 2,2 dihydroxypropane. The activation of ProVP16-II to VP16 occurs with the elimination of glycerol and carbon dioxide.

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