2ME2 inhibits cell growth in hematologic and other malignancies. Cell growth of leukemia and lymphoma cell lines (A) and solid tumor cell lines, including small cell lung cancer, melanoma, and breast cancer (B) was determined. Cell growth was determined in a 3-day culture (n = 4) after treatment with DMSO (▦), 5 μM E2 (▪), or 5 μM 2ME2 (□). Values represent means ± SEM. *Significant differences (P < .005) were observed between 2ME2- and DMSO-treated cells (**P = .05 for the H69 cell line).