Mutations in the conserved Ebox motif disrupt LMO2 promoter activity in K562 cells. (A) Diagram of the position of a deletion series within the ΔBgl region of the LMO2 gene promoter. The position of the Ebox and S8 motifs subjected to site-specific mutation are also noted. (B) Illustration of the activity of the constructs derived from this region, assayed in K562 cells.