Northern blot analyses demonstrating the tissue distribution of LMO2 gene expression and specificity of the distal promoter. (A) Diagram of the human LMO2 gene structure. The 2 promoters are marked by arrows; the translation start site in exon 4 is also indicated. Panels B and D were hybridized with a probe from the coding region of the gene encompassing exons 4 to 6. This probe recognizes transcripts from either the distal or proximal promoter. Panel C is the same blot as shown in panel D, but is hybridized with a probe specific for the distal promoter transcript. A similar analysis of the blot shown in panel B gave no hybridization signal. Panel E was hybridized with both the coding probe and the distal promoter probe as shown.