Figure 1.
Histology, cytology, MALT1, and BCL10 expression in B-cell lymphomas with t(14;18)(q32;q21) involvingMALT1 (A) Hematoxylin and eosin–stained section of case 1 showing typical centrocyte-like cells of MALT lymphoma. (B) Hematoxylin and eosin–stained splenic section of case 2; inset shows the morphology of tumor cells in the marginal zone. (C) Peripheral blood smear of case 2 at diagnosis. May-Grünewald-Giemsa stain. (D) Peripheral blood smear at transformation from case 2 shows blastic cells with abundant cytoplasm, irregular nuclei with nucleoli. May-Grünewald-Giemsa stain. (E) Immunohistochemstry for MALT1 in case 1 showing high levels of the protein in the cytoplasm of all tumor cells. Stained with hematoxylin. (F) Case no. 1 stained with BCL10 Mab 151 showing increased cytoplasmic BCL10 expression. Original magnifications: × 400 (A, B inset, E-F); × 100 (B); and × 1000 (C-D).

Histology, cytology, MALT1, and BCL10 expression in B-cell lymphomas with t(14;18)(q32;q21) involvingMALT1 (A) Hematoxylin and eosin–stained section of case 1 showing typical centrocyte-like cells of MALT lymphoma. (B) Hematoxylin and eosin–stained splenic section of case 2; inset shows the morphology of tumor cells in the marginal zone. (C) Peripheral blood smear of case 2 at diagnosis. May-Grünewald-Giemsa stain. (D) Peripheral blood smear at transformation from case 2 shows blastic cells with abundant cytoplasm, irregular nuclei with nucleoli. May-Grünewald-Giemsa stain. (E) Immunohistochemstry for MALT1 in case 1 showing high levels of the protein in the cytoplasm of all tumor cells. Stained with hematoxylin. (F) Case no. 1 stained with BCL10 Mab 151 showing increased cytoplasmic BCL10 expression. Original magnifications: × 400 (A, B inset, E-F); × 100 (B); and × 1000 (C-D).

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