Consensus regions in human and mouse genomic organization of the 5′ end region upstream of initiation start ATG.

Black boxes indicate regions of homology in the genomic sequence upstream of the translation start site, within both species, human and mouse. Numbers indicate the percentage of identity. Arrowheads show the consensus position of potential transcription factors binding sequences identified in both mouse and human sequences. “P” indicates potential promoter sites. In the third consensus region, the sequence of the 2 5′ UTRs described by Strausberg (GenBank accession no. BC000023) and Kondoh et al (GenBank accession no. NM_001022)25 is indicated. Arrows indicate the 2 transcriptional starts. The gray characters in exon 1 indicate the binding site for a potential κB element, Rel-A, c-Rel.