Distribution of chemokine receptors and of cycling capacity of CD4 T cells.

(A) Representative flow cytometry profiles of the distribution of CCR7 on gated CD4 T cells in HIV-negative and HIV-1–infected patients with chronic and primary infection. The individual data of the different cohorts analyzed are also shown. (B) Distribution of CCR5 and Ki67 on gated CD4⁺CCR7⁻ and CD4⁺CCR7⁺ cells of a representative patient with primary HIV-1 infection. A large proportion of CD4⁺CCR7⁻ cells expressed CCR5 and Ki67. The individual data of the different patients analyzed are also shown. Blood mononuclear cells were stained with anti-CD4 APC, anti-CCR5 CyChrome, anti-CCR7 PE, and anti-Ki67 FITC antibodies.