Human hematopoietic lineage development in secondary NOD/SCID recipients.

Marrow from a primary bnx mouse, engrafted with human CD34⁺/CD38⁻ cells for 1 year, was transplanted into a secondary NOD/SCID recipient. Marrow from the secondary mouse was harvested 6 weeks after transplantation and analyzed by FACS. Multilineage human hematopoietic lineage engraftment was detected, including expression of CD34, which was not detectable in the primary recipient at the time of harvest (data shown in Figures 2and 3).