American Society of Hematology

Fig. 3.

$Fig. 3. Tyr AG490 reduces firm adhesion, but not rolling interactions, of lymphocytes under physiological flow. / Control- and Tyr AG490–treated lymphocytes were perfused at 1 dyne/cm2 in a flow chamber coated with PNAd, CCL21, and VCAM-1 and analyzed for rolling and firmly adherent cells as described in “Materials and methods.” (A) Rolling cells per minute. (B) Sticking fraction of control- and Tyr AG490–treated lymphocytes (n = 4; mean ± SD). Asterisks indicateP < .05.$

Tyr AG490 reduces firm adhesion, but not rolling interactions, of lymphocytes under physiological flow.

Control- and Tyr AG490–treated lymphocytes were perfused at 1 dyne/cm² in a flow chamber coated with PNAd, CCL21, and VCAM-1 and analyzed for rolling and firmly adherent cells as described in “Materials and methods.” (A) Rolling cells per minute. (B) Sticking fraction of control- and Tyr AG490–treated lymphocytes (n = 4; mean ± SD). Asterisks indicateP < .05.

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