Diagrammatic illustration of the CD18 promoter and binding site mutants.

Diagram of the CD18 promoter with the sequence of the RARE shown in bold; arrows indicate the location and orientation of the half-sites. The positions of the Sp1 and ets family–binding sites within the CD18(−96) minimal promoter are underlined, and theets cluster is shaded. The sequences of the CD18 minimal promoter and relevant mutations are presented.