Anti-inflammatory effects of MMP-cleaved MCP analogs in vivo.

Rat paws were injected with carrageenan at time 0. After 24 hours, the volume of the paws was measured, and the paws were injected with either the indicated chemokine analog (50 μg, equivalent dose 250 μg/kg) or phosphate-buffered saline alone. Shown is the change in paw volume from 24 to 36 hours. The negative value for MCP-3(5-76) indicates a reduction in volume at 36 hours compared with 24 hours. *Group differed significantly from vehicle group (P < .05). **Group differed significantly from vehicle (P < .01). Data presented as the mean ± SD; n = 5 per group.