Effect of treatment regimens on DNPS.

(A) In patients randomized to MP (n = 51), the DNPS rate was not significantly inhibited (P = .34), whereas inhibition was evident in patients randomized to LDMTX (P < .01; n = 62) or HDMTX (P < .01; n = 45). (B) A lower frequency of full DNPS inhibition was achieved in patients who received MP compared with MTX plus MP (20% vs 68%; P < .01). HDMTX with MP produced full inhibition in a greater percentage of patients, compared with LDMTX plus MP (78% vs 53%;P = .03).