DNPS and intracellular purine concentrations at diagnosis.

(A) De novo guanine, de novo adenine, and total de novo purine (adenine plus guanine) synthesis rates were higher in patients with T-lineage ALL (n = 32) compared with patients with hyperdiploid (n = 55) or nonhyperdiploid B-lineage ALL (n = 106; P < .01). (B) Intracellular hypoxanthine-plus-inosine and adenine concentrations were higher in patients with hyperdiploid B-lineage ALL (n = 42) compared with patients with nonhyperdiploid B-lineage ALL (n = 93;P < .01), and both B-lineage subtypes (n = 135) had higher hypoxanthine-plus-inosine and adenine levels compared with patients with T-lineage ALL (n = 27; P < .01). Intracellular guanine concentrations were similar among lineages.