Time-activity curves for a representative patient (patient 15).

²¹³Bi rapidly localized to and was retained in the marrow (A), liver (B), and spleen (C) throughout the 1-hour imaging period. Percentage injected activity increased in the marrow and decreased in the liver and spleen after multiple injections of²¹³Bi-HuM195. This pattern was the most commonly observed in the patients who were studied (see “Results”). The red marrow region sampled on gamma camera imaging is scaled to represent total marrow. Plotted activity is adjusted for decay. (—■—) indicates the first injection; (—♦—) indicates the fourth (last) injection.