Inhibitory effect of CD4⁺ T cells tolerized to alloantigen on a naive response to a different alloantigen.

CD4⁺ T cells tolerized to alloantigen nonspecifically down-regulate a naive response to a different alloantigen. B6 CD4⁺ T cells tolerized to bm12 alloantigen down-regulate a naive B6 CD4⁺ T-cell response to B10.BR alloantigen (1 tolerized cell to 10 naive cells). The y-axis presents the mean cpm ± 1 SD of the mean. On the x-axis are days in primary culture.