Fig. 1.
The cell surface expression of CD25 (IL-2Rα) and CD122 (IL-2Rβ).
CTCL cell line HUT78 (A), fresh Sezary cells from a patient with CTCL (B), and pre-B leukemia cell line NALM6 (C) were exposed to 10−8 M or 10−10 M alitretinoin (Panretin) or bexarotene for 48 hours. The cell surface expression of IL-2Rα (CD25) and IL-2Rβ (CD122) were detected by flow cytometry. The dot peak represents isotypic control, the linear peak represents CD25 and CD122 expression in untreated cells, and the filled peak represents the expression of CD25 or CD122 in rexinoid-treated cells.
