Comparison of density of HLA-DR expression on B-CLL cells and normal CD5⁺ B cells.

PBMCs from 61 B-CLL cases and 20 age-matched normal donors were analyzed for the expression of HLA-DR on CD5⁺CD19⁺ cells. Bars represent the mean ± SE of the MFIR of HLA-DR expression on CD5⁺CD19⁺ cells. The differences between the unmutated and mutated subgroups and between the CD38⁺and the CD38⁻ subgroups are significant (P < .001). In addition, the differences between the unmutated subgroup and the normal CD5⁺ B cells, and between the CD38⁺ subgroup and the normal CD5⁺ B cells, are also significant (P < .001).