Fig. 1.
Immunohistochemical localization of Cyr61 and CTGF in advanced atherosclerotic lesions of ApoE−/− mice.

Immunohistochemical localization of Cyr61 and CTGF in advanced atherosclerotic lesions of ApoE−/− mice.

Frozen serial sections were taken from the heart at the aortic valve where prominent atherosclerotic lesions had formed. Sections were treated with H2O2, blocked with normal goat serum, and incubated with normal rabbit IgG (A,D), anti-Cyr61 (B,E), or anti-CTGF (C,F). Antibody localization was detected with a biotinylated secondary antibody, followed by the avidin-biotin-HRP labeling system using diaminobenzidine as the substrate. The sections were counterstained with hematoxylin and eosin. Lesions located at the aortic valve (A-C) and coronary artery (D-F) are shown.

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