Modulation of drug-induced apoptosis by IL-7 in T-ALL cell lines.

Leukemic cells were cultured with IL-7 (25 ng/mL) and either doxorubicin (1 μM and 0.04 μM in KE-37 and MOLT-3, respectively) for 24 hours or dexamethasone (2 μM) for 48 hours. Dot plots show flow cytometric analysis of cells stained with annexin V-FITC and PI. Percentages of viable cells (PI⁻ and annexin V⁻ cells) are indicated. Dot plots of cells in medium alone were identical to that of cells in the presence of IL-7 (not shown).