The DNA enzyme reduced both GM-CSF mRNA and protein in JMML cells.

(A) A decrease of mRNA–GM-CSF was noted after addition of the active, but not the inactive, DNA enzyme (1 μg/mL). Data are from one experiment of one JMML case. Pooled data (means + SEM) from the 8 JMML cases show significant (*) reductions in mRNA (B) and protein (C) for GM-CSF and TNF-α, but not for G-CSF. The data in A and B were obtained from RNAse protection assays.