Inhibition of KS tumor growth by ritonavir.
(A) KSIMM cells (7 × 106cells/mouse) were xenotransplanted into BNX mice (n = 10/group). After visible tumor formation, mice were given intraperitoneal injections of ritonavir, 30 mg/kg per day, for 15 days. The control group received PBS. Tumor growth and progression were monitored by biweekly measurements of tumors with calipers. The treated group differed from the untreated group (P = .001). Wilcoxon rank-sum tests were performed for all comparisons of the means. (B) Photographs depicting a treated versus untreated mouse. The treated mouse was treated with ritonavir for 2 weeks following tumor appearance. The untreated mouse, an age-matched control, received PBS for 2 weeks after tumor appearance.
