Modulation of DC function by ECP.

ECP modulates DC populations, resulting in an increase in CD83⁺, CD86⁺ plasmacytoid DC2 cells with a concordant decrease in CD80⁺, CD123⁺ monocytoid DC1 cells. These stimulate Th2 T-helper cells to secrete Th2 cytokines, which indirectly inhibit Th1-mediated alloreactivity.