American Society of Hematology

Fig. 5.

$Fig. 5. DDABs detect neoepitopes in conformational altered GP IIb/IIIa. / Purified GP IIb/IIIa was fractionated by SDS-PAGE without (lanes 1 and 3) or after preincubation with XP280 (lanes 2, 4, and 5). Lanes 1 and 2 were analyzed by protein stain, lanes 3 and 4 by immunoblotting using patient 307 peak titer PPP, and lane 5 by immunoblotting using patient 307 predose PPP. The mobilities of the “shifted” GP IIb/IIIa and the GP IIb and IIIa subunits are indicated.$

DDABs detect neoepitopes in conformational altered GP IIb/IIIa.

Purified GP IIb/IIIa was fractionated by SDS-PAGE without (lanes 1 and 3) or after preincubation with XP280 (lanes 2, 4, and 5). Lanes 1 and 2 were analyzed by protein stain, lanes 3 and 4 by immunoblotting using patient 307 peak titer PPP, and lane 5 by immunoblotting using patient 307 predose PPP. The mobilities of the “shifted” GP IIb/IIIa and the GP IIb and IIIa subunits are indicated.

This Feature Is Available To Subscribers Only