Rapid clearance of transfused CD47^−/− but not of transfused wild-type (CD47^+/+) RBCs in CD47^−/− NOD mice with overt AIHA.

Clearance of fluorescent-labeled RBCs from normal nonanemic CD47^−/− (open circles) or wild-type (CD47^+/+) mice (closed circles) was followed in anemic CD47^−/− NOD mice with a hematocrit below 25%. Data are mean ± SD from 3 separate recipients and results were independent of the dye used to label the RBCs.