Fig. 2.
Participation of proteoglycans in PF4-mediated inhibition of LDL degradation.

Participation of proteoglycans in PF4-mediated inhibition of LDL degradation.

Degradation of 125I-LDL (5 nM) in the presence or absence of PF4 (20 μg/mL) by WT CHO cells and CHO cells that do not express heparan sulfate (HS). LDL-R–transfected cells were pretreated with buffer (B), heparanase (H), chondroitinase ABC (C), or both heparanase and chondroitinase (HC) for 2 hours at 37°C prior to addition of 125I-LDL. Data are expressed relative to “control” (Ct), which represents degradation of LDL in the absence of PF4. Data are the mean ± SEM of 3 independent experiments, each performed in triplicate.

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