Fig. 6.
IL-21 signaling was not mediated through IL-6 or gp-130.
OH-2 cells were incubated for 72 hours with IL-6 (1 ng/mL) or with IL-21 (40 ng/mL) in the presence or absence of anti-gp130, anti–IL-6, or soluble IL-21 receptor (sIL-21R). DNA synthesis was measured by3H-thymidine incorporation. Similar results were obtained in the cell line IH-1, and data shown are representative of 3 different experiments. Error bars represent ±1 SD of triplicate data.
