Peripheral blood leukocyte and thrombocyte counts after high-dose and low-dose anti-RT7^a mAb treatment.

LEW.1W rats were injected with a high or a low (0.75 mL per 100 g BW) (n = 4) dose of anti-RT7^a mAb. Absolute leukocyte (panel A) and thrombocyte (panel B) numbers were defined from whole blood samples and are shown for both groups: -●- with solid line for the high dose group and -▴- with dashed line for the low-dose group. All animals in the high-dose group died within 6 weeks of observation, whereas all animals in the low-dose group survived indefinitely.