Fig. 5.
Pretransplantation in vivo depletion of CD25+ cells accelerates GVHD.
Anti-CD25 mAb-treated or control-treated thymectomized B6 mice were lethally irradiated and received transplants of BALB/c BM and 15 × 106 spleen. Anti-CD25 mAb was administered at a dose of 0.5 mg/injection on days −10, −7, and −4 relative to day of transplantation. On the x-axis are days after transfer of cells. On the y-axis is the proportion of recipients surviving (n = 8/group;P = .0063).
