Fig. 3.
![Fig. 3. Inhibition of CML progenitors increases with longer exposure to imatinib mesylate. / CFC frequency for CML CD34+ cells, normalized to frequency for cells not exposed to imatinib mesylate, is plotted as a function of exposure time. Data graphed are for 1 μM (- - ♦ - -]), 2 μM (—● - -), and 5 μM (—▾—) imatinib mesylate and shown as the mean ± SEM for replicate experiments (24 hours, n = 7; and 48-96 hours, n = 5). Progenitor frequency is significantly suppressed as exposure time increased from 24 to 96 hours (3 asterisks, P < .001; 2 asterisks,P < .01).](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/99/10/10.1182_blood.v99.10.3792/6/h81022549003.jpeg?Expires=1725165023&Signature=4OjLUVuEbKmBv6mZuQ~yopAUH9Thy2MvgEOkjLeVhagA2n57pARK7j6Vj6t~AiH3UnZ7ky2slbQmbqO75Sc-SHQFQrbhNx0jFCDlEVCSC5IXJymUP2PpR4b2vth26b8FsCLbhxmjg4XstwvXs23CVr0uexBp5BGmN-sZ4XJzkCpMTfgeuAZej~l0q-MPlwzTcojB8dxLN-UN-6AhFoZjdCpVdE-C2AEsso0j6znjiqJn3GywRBxTJQ4z8JXXYDdDgrJVK8KJaM0GKFU3Bd9obpNGAcbbcwziuRJkAmWGzsazxIVtqreiliErxbHVvx8VK~8UFXrH5F3swCffGIH0fg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of CML progenitors increases with longer exposure to imatinib mesylate.
CFC frequency for CML CD34+ cells, normalized to frequency for cells not exposed to imatinib mesylate, is plotted as a function of exposure time. Data graphed are for 1 μM (- - ♦ - -]), 2 μM (—● - -), and 5 μM (—▾—) imatinib mesylate and shown as the mean ± SEM for replicate experiments (24 hours, n = 7; and 48-96 hours, n = 5). Progenitor frequency is significantly suppressed as exposure time increased from 24 to 96 hours (3 asterisks, P < .001; 2 asterisks,P < .01).
