Synthesis of variant fibrinogens in transfected CHO cells.

The concentrations of fibrinogen in the culture media (A) and cell lysates (B) were measured by ELISA as described in “Materials and methods.” The mean values are presented with SDs indicated by the error bars. Concentrations were determined for multiple isolates, indicated in parentheses, of the CHO lines γ379 (3), γ384 (9), γ385 (8), γ386 (10), γ387 (8), γ390 (11), γ395 (11), γ401 (4), γ406 (11), and γ411 (22).