Fig. 1.
Effect of HMBA and NaB on tRA-induced differentiation in NB4, MR-2, and R4 cells.
HMBA and NaB enhanced tRA-induced differentiation in NB4 cells, but not in MR-2 or R4 cells. NB4, MR-2, and R4 cells were treated with 10−7 μM tRA, 0.5 mM NaB, and 2 mM HMBA, alone or in combination as labeled in the bottom of the Figure, for 3 days. Differentiation was determined by NBT reduction assay. The data were the mean of 3 independent experiments with SD.
