Model of C/EBPα modulating PU.1 activity and its effect on target genes of PU.1.

C/EBPα interacts with PU.1. This interaction is between the β3-β4 region of the DNA-binding domain of PU.1 and the leucine zipper of the DNA-binding domain of C/EBPα. C/EBPα displaces the coactivator c-Jun from binding to PU.1. C/EBPα blocks PU.1 function and down-regulates its target genes. C/EBPα blocks PU.1-induced dendritic cell differentiation and drives the cells to granulocytes.