Fig. 10.
Effect of the NT analogues on the expression of cell-cycle control molecules.
The effect in SK-N-MC neuroepithelioma cells of the most cytotoxic NT analogues, NT and N4mT, compared with 311 on the protein levels of (A) cdk2, cdk4, and β-actin (loading control); or (B) cyclins A, E, D1, D2, D3, and β-actin (loading control). Western blot analysis was performed as described in “Materials and methods.” The results shown are typical of 2 experiments performed.
