Antiproliferative effects of the most active chelators in neoplastic and normal cells.

The influence of the most cytotoxic NT analogues, 311m, and 311 (internal standard) on the proliferation of SK-N-MC neuroepithelioma cells (S) as compared with MRC-5 fibroblasts (F). Cells were incubated in the presence and absence of the chelators (0-25 μM) for 72 hours at 37°C. After this incubation period, cellular density was measured with the MTT assay (see “Materials and methods”). Each data point represents the mean of 2 replicates in a typical experiment of 3 experiments performed.