Somatic mutations in amyloid and polyclonal Vλ regions from BMPCs.

Somatic mutation rates for specific subgroups are reported as means and 95% CIs. Overall, the frequency of somatic changes is significantly higher in polyclonal than in amyloid λ light chains. In amyloidosis, the λIII light chains are more mutated than the λVI (6a) light chains (*P = .019). This holds true also for3r light chains versus 6a light chains (°P = .018). Germline gene 6a is the single germline gene of the λVI family. P indicates polyclonal; A, amyloidosis.