Growth of tumor in the SCID-hu mouse.

(A) X-ray showing the 2 bone implants just prior to injection of tumor cells into the left bone (arrow). (B) The same animal as in the left panel is shown 8 weeks after injection of cells expressing soluble syndecan-1 ectodomain. Note the injected bone shows evidence of osteolysis and that the primary tumor has enlarged and surrounds the bone.